Screening by changes in stereotypical behavior during cell motility

Conformational changes during kinesin motility.

Nucleotide-dependent movements of the head and neck of kinesin have been visualized by cryoelectron microscopy and have been inferred from single-molecule studies. Key predictions of the hand-over-hand model for dimeric kinesin have been confirmed, and a novel processivity mechanism for the one-headed, kinesin-related motor KIF1A has been discovered.

Types of Equine Stereotypical Behavior ”

Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility.

Focal adhesion kinase (FAK) controls cellular adhesion and motility processes by its tight link to integrin- and extracellular-matrix-mediated signaling. To explore the dynamics of the regulation of FAK, we constructed a FRET-based probe that visualizes conformational rearrangements of the FERM domain of FAK in living cells. The sensor reports on an integrin-mediated conformational change in FA...

Stereotypical fingertip trajectories during grasp.

The kinematics of movement of all five digits was analyzed during reach-and-grasp tasks for a variety of objects. Ten healthy subjects performed 20 trials involving the grasp of five objects of distinct size and shape. Joint angles were recorded, and digit trajectories were computed using forward kinematics. For a given subject, fingertip trajectories were consistent across trials. The differen...

Stereotypical resting behavior of the sperm whale

by side. Conservation measures must thus work to ensure that on balance growth outpaces destruction, and that the natural ability of reefs to recover from disturbance ('resilience') is maintained. To date, marine protected areas have been the focus of most attention. Conspicuous successes include placing about one third of the Great Barrier Reef in no-take zones, and protection of the Northwest...